Worms are important source of immunomodulatory proteins that could be used in the development of new drugs for the treatment of immune-mediated diseases such as inflammatory bowel disease (IBD). A research group in Belgium investigated the therapeutic effect of worm-derived proteins on experimental colitis in mice. Treatment with worm proteins ameliorated motility disturbances during murine experimental colitis. This suggests that worm proteins have great potential to be used as therapeutic agents in IBD.