In any battle, sizing up one's opponent is a critical first step. For researchers fighting a bacterial infection, that means assessing every nook and cranny of the malicious microorganism and identifying which to attack. In Spain, scientists are devising maneuvers they hope will take out bacteria at their molecular knees, and they are optimistic a recent advance will yield therapies for a number of infections, including antibiotic-resistant strains delivering blow after blow across the globe.