Colorectal cancer is a leading cause of death worldwide. Hydrophobic proteins are a class of proteins that are involved in many cellular functions in the body. A group of researchers from Malaysia analyzed differentially expressed hydrophobic proteins in colorectal cancer and normal tissues. Four hydrophobic proteins were found to be highly expressed in colorectal cancer tissues, these proteins may serve as potential biomarkers for colorectal cancer that can be used for its detection and treatment.