Researchers have determined how cells regulate the chromosome/microtubule interface, which is central to proper chromosomal distribution during cell division. The chromosome/microtubule interface is critical during cell division. If a microtubule attaches incorrectly to a chromosome and cell division proceeds, the chromosomes may divide unevenly, resulting in cells with an incorrect number of chromosomes. Aberrant distribution of chromosomes can lead to cancer or premature cell death.